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• Kim Jh, serrA-PiCAmAl X, tAmBe dt, zhou eh, PArK Cy, sAdAti m. Propulsion and navi-
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• l B G, r ot, m Jd, G v, l n, i v. An in vitro study to assess
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Highlights
The group belongs to the CIBER of Respiratory Diseases and is an associated
group of CIBER of Bioengineering, Biomaterials, and Nanomedicine. In CiberES

our research is currently focused on the Corporate Programs on Acute Lung Injury

Program (ALI) and Sleep Apnea - Hypopnea Syndrome (SAHS). In CiberBBN we
participate in the project Multimodal Diagnosis by Signal Interpretation of the Res-

piratory System oriented to Pulmonary Diseases and Sleep Disorders (MUDIRES-
2PSD). Our research is interdisciplinary and is developed in collaboration with other

groups of the CIBER. We transfer technology by means of contracts with companies

of respiratory medical devices.

In SAHS program our group is active in the study of the pathophysiology and con-
sequences of the disease. Members of the group have led two publications in 2013

based on a mouse model of melanoma and intermittent hypoxia, showing for the

first time that intermittent hypoxia similar to OSA increases tumor growth - proba-
bly via overexpression of vascular endothelial growth factor – and promotes tumor

metastasis to the lung. We have also published two studies in patients revealing a
significant incidence/mortality of cancer in patients with SAHS. The group leads a

Work Package of the European project CHROMED on home monitoring in patients

with chronic respiratory diseases. We have also developed a platform for telematics
control of CPAP treatment in patients with sleep apnea at home.

Within the ALI program and in order to understand the mechanisms that govern

the cell-matrix interplay in lung repair/regeneration we have characterized the me-

chanical properties of the lung extracellular matrix by means of nanotechnologies.
This work has revealed for the first time the mechanical heterogeneity of the cell

niche in different lung structures. In addition, we have evaluated the effect of diffe- 13
rent decellularization procedures on the nanomechanics of lung matrix. Moreover, 20
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the mechanical forces governing collective migration involved in the tissue repair OR
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mechanisms have been identified. We have also developed a lab-on-a-chip device RE
to study the cellular response to cyclic deformation.
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