Page 82 - MemoriaBBN-Eng

RESEARCH GROUPS

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PROGRAMME:
Nucleic Acid Chemistry Group
Nanomedicine

Group Members
Lead Researcher

STAFF MEMBERS
Eritja Casadellà, Ramón

Avi Andrs, Ana Mara
Grijalvo Torrijo, Santiago
Contact:

Instituto de Quimica Avanzada de Cataluña. ASSOCIATED MEMBERS
Fbrega Claveria, Carme
C/ Jordi Girona, 18-26. Barcelona.
Phone: (+34) 93 400 61 45
CONTRIBUTORS
E.mail: [email protected] · http://www.iqac.csic.es
Alagia, Adele

Prez Rentero, Sonia
Terrazas Martnez, Montserrat
Main lines of research
Tintor Gazulla, Mara

• Development of new molecules which bind to DNA. Study of the interaction
of drugs with DNA.

• Synthesis of oligonucleotides with non-natural nucleosides.

• Synthesis of modified RNA for the inhibition of gene expression by the RNA
interference mechanism.

• Development of novel formulations for gene therapy and gene silencing.

• Synthesis and structural studies of quadruplex-forming oligonucleotides.
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• Triple helix-forming oligonucleotides. Application of triplex affinity capture T
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for the analysis of nucleic acid sequences.
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• Two-dimensional DNA crystals. Origami DNA.
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• Synthesis of oligonucleotide-peptide conjugates.
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• Use of oligonucleotides in biosensors. Surface functionalization with nucleic A
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acid derivatives.
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• Study of DNA repair processes with the aim of developing inhibitors that R-
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can be used to avoid resistance to chemotherapy.
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