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• m-r G, m-l P, s C, G-C mJ. Multifunctional polyu-
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í

The research activities have mainly focused to the design of advanced multi-
Highlights
functional nanocarriers for the therapy of neurodegenerative diseases performed
in the frame of the CIBER-BBN intramural project Nano-Trans-Brain. Polymeric ó

nanoparticles with tuneable characteristics have been prepared by nano-emulsion

templating and functionalized with carbosilane dendrons and monoclonal antibo-
dies for the specific blood-brain barrier (BBB) targeting. Binding of oligonucleoti-

des and encapsulation of antiapoptotic drugs to the nanoparticles have been suc- ó
cessfully achieved.In vitro and in vivo evaluation of the designed nanocarriers has

showed that they are appropriate for the intended application. The nano-emulsion

templating technology developed in our group allows nanoparticle size control and
high drug entrapment efficiency using biocompatible components. Moreover, this é
é
technology can be performed under mild processing conditions (e.g. at low tempe-

rature, 25oC, allowing the preservation of pharmacological properties of drug mo-
lecules chemically unstable at high temperature), requires simple equipment and

it is easily scalable. The group has also performed research activities in the frame
of the following projects: “Multifunctional nanotechnology for selective detection

and treatment of cancer” (FP7-NMP-2010-LARGE-4; C-NMP/0878), “Nanoparti- í

cles in food: analytical methods for detection and characterization” FP7-245162,
“Tecnologas de autoagregacin de molculas anfiflicas para aplicaciones terapéu-

ticas” (CTQ2011-29336-C03-02), “Estudios experimentales y teóricos de proce-

sos de autoagregacin de compuestos anfifilicos biocompatibles para el diseño de í
nanomateriales avanzados”(CTQ2011-29336-C03-01) and 17) and “Formación de
13
emulsiones de Pickering mediante mtodos de baja energa para la preparación 20
de nuevos materiales porosos nanocompuestos” (CTQ2011- 23842). The most im- T
OR
portant outcomes of the results obtained are reflected in 22 indexed publications P
RE
and 3 book chapters, as well as in the presentation of 18 (two of them invited) oral L
and 23 poster presentations in national and international conferences. Five PhD A
NU
and 3 Master thesis have been presented.
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