Page 145 - MemoriaBBN-Eng

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• C v, m-s F, G l, A m, s J, v n. Enhancing of
Most relevant eBriánArtínAAvedrAómezrrueBoAntAmAriAilABoA
plasmonic photothermal therapy through heat-inducible transgene activity.Nanome-
scientific dicine. 2013 Jul;9(5):646-56.

articles
• veGAs mr, mArtín-hervAs C. The superolateral thigh flap: cadaver and computed
tomographic angiography studies with a clinical series.Plast Reconstr Surg. 2013

Feb;131(2):310-22.

• vAllés G, Pérez C, Boré A, mArtín-sAAvedrA F, sAldAñA l, vilABoA n. Simvastatin prevents
the induction of interleukin-6 gene expression by titanium particles in human osteo-

blastic cells.Acta Biomater. 2013 Jan;9(1):4916-25.

• Frutos e., González-CArrAsCo Jl.. A method to assess the fracture toughness of inter-
metallic coatings by ultramicroindentation techniques: Applicability to coated medi-

cal stainless steelACTA MATER. 2013;61:1886-1894.

• mArtín-sAAvedrA Fm, Wilson CG, voellmy r, vilABoA n, FrAnCesChi rt. Spatiotemporal con-
trol of vascular endothelial growth factor expression using a heat-shock-activated, ra-

pamycin-dependent gene switch.Hum Gene Ther Methods. 2013 Jun;24(3):160-70.

Highlights
The group of Bone Physiopathology and Biomaterials has performed a thorough
characterization of several modifications of medical 316 LVM steel and Ti64 alloys,

including oxidation, thermolectrical power, mechanical and biocompatibility tests.
The group has progressed in the development of gene switches for the spatial and

temporal regulation of therapeutic transgenes, which are currently being adapted

to control osteogenic and angiogenic growth factors in tissue engineering applica-
tions. Furthermore, the capacity of plasmonic nanoparticles to activate transgenes

driven by hsp promoters upon near infrared laser irradiation has been demonstra-

ted. In addition to their participation in 12 clinical trials for medical interventions
in bone-related diseases, the clinical scientists of the group have continued their

retrospective studies on total hip arthroplasties. Moreover, the group has shown
that statins may ameliorate the wear debris-mediated periprosthetic osteolysis by

down-regulating IL-6, a key player in this inflammatory process. The group funded

its activities by means of grants from MINECO, ISCIII and research contracts with
the industry.

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