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• C Jl, . Unconventional microbial systems for the cost-efficient production of
Most relevant orChero
high-quality protein therapeutics.Biotechnology advances. 2013;Número: 15 Volu-
scientific me: 31 Issue: 2 Pages: (15, 31, 2):140-153 .

articles
• serAs-FrAnzoso J, PeeBo K, luis CorChero J, tsimBouri Pm, unzuetA u, rinAs u et Al.. A
nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein

drugs.Nanomedicine (Lond). 2013 Oct;8(10):1587-99.

• tAtKieWiCz Wi, serAs-FrAnzoso J, GArCíA-Fruitós e, vAzquez e, ventosA n, PeeBo K et Al..
Two-dimensional microscale engineering of protein-based nanoparticles for cell gui-

dance.ACS Nano. 2013 Jun 25;7(6):4774-84.

• serAs-FrAnzoso J, steurer C, roldán m, vendrell m, vidAurre-AGut C, tArruellA A et Al..
Functionalization of 3D scaffolds with protein-releasing biomaterials for intracellular

delivery.J Control Release. 2013 Oct 10;171(1):63-72.

• unzuetA u, sACCArdo P, dominGo-esPín J, CedAno J, ConChillo-solé o, GArCíA-Fruitós e et
.. Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses
Al
for gene delivery.Nanomedicine. 2013 Nov 21;.

Highlights
The group has devoted most of its activity in 2013 to the resolution of the molecu-
lar architecture of bacterial inclusion bodies as nanostructured materials. In parti-

cular, it has been determined that the capacity to act as slow release systems both

as NANOPILLS or as BIOSCAFFOLDS depends on the proportion of amyloid protein
that comprises then, organized in the a sponge-like form. By both regulating the

temperature of production and by the right choice of the genetic background, the

proportion of amyloid material can be increased (greater mechanical stability and
lower protein release) or narrowed (less mechanical stability but greater release).

This study is related to the use of the inclusion bodies in regenerative medicine
and to their potential as therapeutic agents, which is around the activities asso-

ciated with the licensed patent WO2010131117.

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