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served vessels has also been approached. Finally, tissue engineering techniques are
used for the purpose of improving the viability of prosthetic materials through the

creation of a cell coating and the incorporation of bioactive substances.

• OSTEOGENIC REGENERATION. This research line was introduced in our department
recently as a result of collaboration with the group COFIBIC, coordinating group,

of an autonomic project BIOINTEL, that has continued with another project, “BITI”
award in 2010 until 2014. We have worked on the regeneration of bone defects

using tissue engineering techniques and on the biocompatibility of bone substitutes
in different experimental models.

• PAsCuAl G, sotomAyor s, rodríGuez m, BAyon y, Bellón Jm. Behaviour of a new composite
Most relevant
mesh for the repair of full-thickness abdominal wall defects in a rabbit model.PLoS ñ
scientific One. 2013;8(11):e80647.

articles
• m. Fernández-Gutierrez, e. olivAres, G. PAsCuAl, J.m. Bellón, J. sAn román. Low-density

polypropylene meshes coated with resorbable and biocompatible hydrophilic polymers íá
as controlled release agents of antibioticsACTA BIOMATER. 2013;9(4):6006-6018.
ó
• G-P r, P G, r m, P-K B, B Jm. Do collagen
ArCAumArinoAsCuAlodríGuezérezöhlerellón
meshes offer any benefits over precludeVR ePTFE implants in contaminated surgical
fields? A comparative in vitro and in vivo studyJ Biomed Mat Res B. 2013;:1-10.
ó
• h-G B, P e, G J, P G, B Jm, C B. Mechanical res-
ernndezAsCneñArAsAAsCuAlellónAlvo
ponse of the herniated human abdomen to the placement of different prostheses.J
Biomech Eng. 2013 May;135(5):51004.
ô
é

• slove s, lAnnoy m, BehmoArAs J, Pezet m, sloBodA n, lAColley P et Al.. Potassium channel
openers increase aortic elastic fiber formation and reverse the genetically determi-

ned elastin deficit in the BN rat.Hypertension. 2013 Oct;62(4):794-801.

The second year of the coordinated national project DPI2011-27939-C02-02, “Dise-
Highlights
o de prtesis biomimticas con adaptación a las propiedades del tejido receptor”,
included in our main line of research in abdominal wall hernia repair, as part of the

intramural project ABDOMESH, has been carried out successfully during 2013. One
contract of transfer, related to prosthetic infection, has been signed with the company

Covidien and another one was signed with LifeCell to study the behavior of different
collagen biological prostheses. Scientific production of this research line has been very
ñ
consistent during 2013, with a total of ten publications (two of which included in the
1st quartile of the JCR and 4 in the 2nd) including two book chapters. Also, concerning

this line of research several communications have been presented at the 15th Ameri-
can Hernia Repair Congress held in Orlando (USA) and TERMIS-EU Conference held in

Istanbul (Turkey).
Related to our line of research in repair of skin defects, one paper has been published

in Histology and Histopathology about improving healing in ischemic wounds by an an-
giogenesis promoter in combination with autologous stem/progenitor cells. During this 13
20
year one important contract of transfer, with the company Novartis, has been signed in T
the area of pharmacological healing.
OR
P
With respect to the vascular repair line of research, during 2013, the most important RE
L
paper has been published in Hypertension journal (1st decile of JCR) in collaboration A
with Inserm, U698, Hpital Bichat (Paris). A National Research Project, about venous NU
N
insufficiency, funded by the Instituto de Salud Carlos III, has been awarded in 2013. A
Several communications have been presented at the XXIX LIAC Meeting on Vascular N /
B
Research, held in Alghero (Italy), Elastin, Elastic Fibers & Microfibrils. Gordon Research -B
Conference, Biddeford, (USA) and at the V International Congress of Histology and R
BE
Tissue Engineering/ XVII SEHIT Congress of Logroo (Spain).
CI

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