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and integrative data analysis. The goals are the identification of new biomarkers of tumor

progression, tested on human samples, and new therapeutic targets, validated by RNAi or
specific drugs, with emphasis on metabolic regulators that are differentially activated in me-

tastatic CSCs or non-CSCs.

• MONITORING CONVENTIONAL TUMOUR THERAPY. The non invasive imaging platform permits
the measurement of tumour response to therapeutic strategies during time, in the same expe-

rimental animal, improving data consistency and reproducibility, as well as, savings in animal
resources.

Most relevant • BAGó Jr, AlievA m, soler C, ruBio n, BlAnCo J. Endothelial differentiation of adipose tissue-
derived mesenchymal stromal cells in glioma tumors: implications for cell-based therapy.
scientific
Mol Ther. 2013 Sep;21(9):1758-66.
articles
• B Jr, A e, A m, s-B C, v oF, C s .. In vivo biolumines- í
AGóGuilArlievAolerotiJAilAlAroset Al
cence imaging of cell differentiation in biomaterials: a platform for scaffold development.
Tissue Eng Part A. 2013 Mar;19(5-6):593-603.
ó

• BAG Jr, soler-BotiJA C, CAsAní l, AGuilAr e, AlievA m, ruBio n et Al.. Bioluminescence ima-
ging of cardiomyogenic and vascular differentiation of cardiac and subcutaneous adipose
é
tissue-derived progenitor cells in fibrin patches in a myocardium infarct model.Int J Car-
diol. 2013 Nov 15;169(4):288-95.

• stresinG v, BAltzisKuetA e, ruBio n, BlAnCo J, ArriBA mC, vAlls J et Al.. Peroxiredoxin 2 speci-
fically regulates the oxidative and metabolic stress response of human metastatic breast

cancer cells in lungs.Oncogene. 2013 Feb 7;32(6):724-35.
• C l, m-Cé o, A Jl, G s, r n, d A .. Acid ceramidase as a
AmAChoeCAortsBAdArCíAuBioíAzet Al
therapeutic target in metastatic prostate cancer.J Lipid Res. 2013 May;54(5):1207-20.

í

The Cell Therapy group has focused its research activity during recent years in two interre- é
Highlights
lated aspects of cell therapy: Regenerative Medicine and Tumor Therapy, as well as in the
understanding of the interactions between tumor and therapeutic stem cells.
é
Research highlights during year 2013 have been: The validation and subsequent application

of the Biomaterial Analysis Platform, resulting in publications in Tissue Engineering, Interna-
tional Journal of Cardiology and J. Biomed. Mater. Res. (regenerative medicine field); and the

demonstration that differentiation of therapy-delivering mesenchymal stem cells to the en-
dothelial lineage and their association with the tumor stem cell niche are required for effective
tumor cell killing (tumor therapy). The group has also participated in several collaborative

projects requiring bioluminescence imaging to noninvasively evaluate tumor growth, with re-
sults published in Oncogene and Journal of Lipid Research, among other journals.
á

In 2013, Olaia Fernandez successfully defended her Doctoral Thesis.

During year 2013 the team was supported by grants from 3 different national projects (MINE-

CO), an “autonomic project” and a “research internationalization project”, the latter directed
towards the development of photo-dynamic nanoparticles for tumor therapy. In addition, the
group signed several contracts for use of bioluminescence imaging technology.
í
In the same year, the team initiated its activities as member of TerCel, the Thematic Network
13
for Cooperative Research in Cell Therapy (ISCiii), focusing its effort on the analysis of safety 20
and bio-distribution of the cell types studied by the consortium.
T
OR
The group has generated publications in collaboration with othe research teams: “Biomateria- P
RE
les para Terapia Regenerativa” (IBEC); “Laboratorio de Bioingeniera y Regeneracion Tisular” éL
(UMA-Bionand); “Laboratorio de Patognesis de la Metstasis” (IDIBELL), “Insuficiencia Car- A
daca y y Regeneracion Cardaca” (Hospital Germans Trias i Pujol) and “Unidad de Investiga- NU
N
cion en Molculas Bioactivas” (IQAC-CSIC). In addition, the group has worked in collaboration A
with the “Photosciences and Phtotonics” group of the National Institute for Interdisciplinary N /
B
Science (India), supported by a Research Internationalization grant (MINECO), and with “La- -B
boratorio de Fisiopatolgia Ortopdica e Medicina Regenerativa” (Insituto Ortopdico Rizzoli, R
BE
Bolonia, Italy.
CI

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