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Most relevant • lóPez-PAniAGuA m, nieto-miGuel t, de lA mAtA A, GAlindo s, herrerAs Jm, CorrAles rm et
Al.. Consecutive expansion of limbal epithelial stem cells from a single limbal biopsy.
scientific
Curr Eye Res. 2013 May;38(5):537-49.
articles
• nieto-miGuel t, GAlindo s, reinoso r, Corell A, mArtino m, Pérez-simón JA et Al.. In vitro
simulation of corneal epithelium microenvironment induces a corneal epithelial-like

cell phenotype from human adipose tissue mesenchymal stem cells.Curr Eye Res.
2013 Sep;38(9):933-44.

• m A, n-m t, l-P m, G s, A mr, G-F
de lA AtAietoiGuelóPezAniAGuAAlindoGuilArArCíAernández
l et Al.. Chitosan-gelatin biopolymers as carrier substrata for limbal epithelial stem
cells.J Mater Sci Mater Med. 2013 Dec;24(12):2819-29.

• tesón m, González-GArCíA mJ, lóPez-miGuel A, enríquez-de-sAlAmAnCA A, mArtín-mon-
tAñez v, Benito mJ et Al.. Influence of a controlled environment simulating an in-

flight airplane cabin on dry eye disease.Invest Ophthalmol Vis Sci. 2013 Mar
1;54(3):2093-9.

• mí-m v, l-m A, A C, m me, G-m Jm, C
ArtnontAñezóPeziGuelrroyoAteoonzálezéiJomeAlonGe
m et Al.. Influence of environmental factors in the in vitro dehydration of hydrogel
and silicone hydrogel contact lenses.J Biomed Mater Res B Appl Biomater. 2013 Oct

21;0(0):1-8.

The IOBA-UVa group coordinated the intramural project BioScaff-EYE, designed
Highlights
to engineer the natural niche of corneal stem cells (SC) to treat ocular surface

failure due to limbal SC deficiency (LSCD). At the very end of 2012, this intramu-
ral project was transferred to Ferrer, a leading Spanish pharmaceutical company.

Since then, the three academic groups: IOBA-UVa, Valladolid (PI and coordinator,

Margarita Calonge), IBEC, Barcelone (PI, Elisabeth Engel), and NanoBioCel, Uni-
versity of The Vasc Country in Vitoria (PI, José Luis Pedraz), have been closely

working together with CIBER-BBN personnel and Ferrer Advanced Biotherapeutics
to lead this project to the desired end at maximum speed. As a result, the in vitro

and the in vivo experimental work have been intensified. Additionally, IOBA-UVa

kept recruiting patients for the randomized double-masked clinical trial for the
same pathology, LSCD syndrome, in which either limbal cells or bone marrow-

derived stem cells are being tested and followed for one year after transplantation

(ClinicalTrials.gov Identifier: NCT01562002). Results of this clinical trial will be
available at the beginning of 2015.

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